北京免疫学会第八届常务理事介绍（刘万里）

刘万里 常务理事

清华大学生命学院长聘终身教授和博导，清华大学免疫学研究所、清华北大生命科学联合中心研究员。获国家杰出青年基金、教育部长江学者特聘教授、科技部科技创新领军人才等项目支持。聚焦B淋巴细胞基础免疫学研究，致力于整合交叉学科平台以对B淋巴细胞免疫识别、免疫活化及相关免疫疾病的致病机理进行研究。在B淋巴细胞活化调控与相关疾病（Science、J Clin Invest、J Exp Med、Cell Research、Leukemia和eLife 2019a）、脂类代谢网络调控淋巴细胞活化新途径（Cell、PLoS Biology、Science Immunology、Cell Reports和Nature Communications）、抗原受体微簇体调控淋巴细胞活化新机制（Science Advances、PNAS和eLife 2019b）和机械力感知调控B细胞活化新模型（J Cell Biol、Science Signaling和eLife2015/2017）等研究方向发表通讯作者论文（含共同通讯），相关成果入选2018年度中国十大医学科技新闻。获中国青年科技奖、药明康德生命化学杰出成就奖、谈家桢生命科学奖、树兰医学奖等奖项。受邀在国内外学术会议交流（Keystone B细胞会议， EMBO抗原受体信号转导会议、美国风湿病年会等）。研究得到基金委重点项目（主持）、专项项目（课题组长）、创新群体（参与）；科技部863（青年科学家项目）、973（课题组长）和重点研发计划（首席科学家）等支持。获教育部自然科学奖二等奖、中华医学科技奖二等奖和北京市医学科技奖一等奖等奖项。任中国免疫学杂志、 Rheumatology & Autoimmunity和Fundamental Research期刊编委；为 NSFC、MOST、NIH、UK Wellcome Trust Foundation、Canada Natural Sciences and Engineering Research Council、Netherlands Organization for Scientific Research和RGC等评审项目。

代表性论文（*通信作者，#co-first author）：

[1]     Bing Yang^#, Zhen Zhang^#, Xiangjun Chen^#, Xu-Yan Wang, Shishang Qin, Liaoqi Du, Changjiang Yang, Liyu Zhu, Wenbo Sun, Yongjie Zhu, Qinwen Zheng, Shidong Zhao, Quan Wang, Long Zhao, Yilin Lin, Jinghe Huang, Fan Wu, Lu Lu, Fei Wang, Wenjie Zheng, Xiao-Hua Zhou, Xiaozhen Zhao, Ziye Wang, Sun Xiao-Lin, Yingjiang Ye, Shan Wang, Zhanguo Li, Hai Qi, Zemin Zhang, Dong-Ming Kuang, Lei Zhang, Zhanlong Shen*, Wanli Liu*. An Asian-specific variant in human IgG1 represses colorectal tumorigenesis by shaping the tumor microenvironment. J Clin Invest. 2022, e153454. doi: 10.1172/JCI153454.

[2]     Jing Chen^#, Xiaochen Zhang^#, Liping Li^#, Xianqiang Ma, Chunxiao Yang, Zhaodi Liu, Chenyang Li, Maria J. Fernandez-Cabezudo, Basel K. al-Ramadi, Chuan Wu, Weishan Huang, Yong Zhang*, Yonghui Zhang*, Wanli Liu*. Farnesyl pyrophosphate is a new danger signal inducing acute cell death. PLoS Biology. 2021, 19:e3001134. doi: 10.1371/journal.pbio.3001134.

[3]     Xingwang Zhao^#, Hengyi Xie^#, Meng Zhao^#, Asma Ahsan, Xinxin Li, Fei Wang, Junyang Yi, Zhiyong Yang, Chuan Wu, Indu Raman, Quan-Zhen Li*, Tae Jin Kim*, Wanli Liu*. Fc receptor-like 1 intrinsically recruits c-Abl to enhance B cell activation and function. Science Advances. 2019, 5, eaaw0315, DOI: 10.1126/sciadv.aaw0315

[4]     Zhixun Shen^#, Sichen Liu^#, Xinxin Li^#, Zhengpeng Wan, Youxiang Mao, Chunlai Chen, Wanli Liu*. Conformational change within the extracellular domain of B cell receptor in B cell activation upon antigen binding. eLife. 2019, 8, doi: 10.7554/eLife.42271.

[5]     Chenguang Xu^#, Yan Fang^#, Zhiyong Yang, Yukai Jing, Yonghui Zhang, Chaohong Liu*, Wanli Liu*. MARCKS regulates tonic and chronic active B cell receptor signaling. Leukemia. 2019, 33:710-729.

[6]     Xiangjun Chen, Xiaolin Sun^#, Wei Yang^#, Bing Yang^#, Xiaozhen Zhao, Shuting Chen1, Lili He, Hui Chen, Changmei Yang, Le Xiao, Zai Chang, Jianping Guo, Jing He, Fuping Zhang, Fang Zheng, Zhibin Hu, Zhiyong Yang, Jizhong Lou, Wenjie Zheng, Hai Qi, Chenqi Xu, Hong Zhang, Hongying Shan, Xu-jie Zhou, Qingwen Wang, Yi Shi, Luhua Lai, Zhanguo Li *, Wanli Liu*. An autoimmune disease variant of IgG1 modulates B-cell activation and differentiation. Science. 2018, 362:700-705.

[7]     Yun Xia^#, Yonghua Xie^#, Zhengsen Yu^#, Hongying Xiao, Guimei Jiang, Xiaoying Zhou, Yunyun Yang, Xin Li, Meng Zhao, Liping Li, Mingke Zheng, Shuai Han, Zhaoyun Zong, Xianbin Meng, Haiteng Deng, Huahu Ye, Yunzhi Fa, Haitao Wu, Eric Oldfield, Xiaoyu Hu, Wanli Liu*, Yan Shi*, Yonghui Zhang*. The mevalonate pathway is a druggable target for vaccine adjuvant discovery. Cell. 2018, 175:1059-1073.

[8]     Junyi Wang^#, Feng Lin^#, Zhengpeng Wan, Xiaolin Sun, Yun Lu, Jianyong Huang, Fei Wang, Yingyue Zeng, Ying-Hua Chen, Yan Shi, Wenjie Zheng, Zhanguo Li, Chunyang Xiong*, Wanli Liu*. Profiling the origin, dynamics, and function of traction force in B cell activation. Science Signaling. 2018, 11. pii: eaai9192. doi: 10.1126/scisignal.aai9192. (Cover story)

[9]     Zhengpeng Wan, Chenguang Xu^#, Xiangjun Chen^#, Hengyi Xie^#, Zongyu Li^#, Jing Wang^#, Xingyu Ji, Haodong Chen, Qinghua Ji, Samina Shaheen, Yang Xu, Fei Wang, Zhuo Tang, Ji-Shen Zheng, Wei Chen, Jizhong Lou, Wanli Liu*. PI(4,5)P2 determines the threshold of mechanical force-induced B cell activation. J Cell Biol. 2018, 217:2565-2582.

[10]  Chenguang Xu, Hengyi Xie, Xingdong Guo, Haipeng Gong, Lei Liu, Hai Qi, Chenqi Xu, Wanli Liu*. A PIP2-derived amplification loop fuels the sustained initiation of B cell activation. Science Immunology. 2017, 2. pii: eaan0787. doi: 10.1126/sciimmunol.aan0787.

[11]  Jing Wang, Liling Xu, Samina Shaheen, Sichen Liu, Wenjie Zheng, Xiaolin Sun, Zhanguo Li, Wanli Liu*. Growth of B cell receptor microclusters is regulated by PIP2 and PIP3 equilibrium and Dock2 recruitment and activation. Cell Reports. 2017, 21:2541-2557.

[12]  Liling Xu^#, Mengdie Xia^#, Jun Guo^#, Xiaolin Sun^#, Hua Li, Chenguang Xu, Xiaomei Gu, Haowen Zhang, Junyang Yi, Yan Fang, Hengyi Xie, Jing Wang, Zhixun Shen, Boxin Xue, Yujie Sun, Tobias Meckel, Ying-Hua Chen, Zhibin Hu, Zhanguo Li*, Chenqi Xu*, Haipeng Gong*, Wanli Liu*. Impairment on the lateral mobility induced by structural changes underlies the functional deficiency of the lupus-associated polymorphism FcγRIIB-T232. J Exp Med. 2016, 213:2707-2727.

[13]  Jing Wang^#, Shan Tang^#, Zhengpeng Wan, Yiren Gao, Yiyun Cao, Junyang Yi, Yanyan Si, Haowen Zhang, Lei Liu* and Wanli Liu*. Utilization of a photoactivatable antigen system to examine B cell probing termination and the B cell receptor sorting mechanisms during B cell activation. PNAS. 2016, 113:E558-567.

[14]  Zhengpeng Wan, Xiangjun Chen, Haodong Chen, Qinghua Ji, Yingjia Chen, Jing Wang, Yiyun Cao, Fei Wang, Jizhong Lou, Zhuo Tang and Wanli Liu*. The activation of IgM- or isotype-switched IgG- and IgE-BCR exhibits distinct mechanical force sensitivity and threshold. eLife. 2015, 4:e06925 (Faculty of 1000 recommended paper)

[15]  Xiangjun Chen#, Weiling Pan#, Yinqiang Sui, Hua Li, Xiaoshan Shi, Xingdong Guo, Hai Qi, Chenqi Xu* and Wanli Liu*. Acidic phospholipids govern the enhanced activation of IgG-B cell receptor. Nature Communications. 2015, 6:8552